Neuroverse is Cytognosis Foundation's first major scientific program. It builds a
continuous, multimodal, individual-level coordinate system for the human brain and psyche
— the first instantiation of the Cytoverse GPS-for-Health framework applied to psychiatry
and neurodegeneration.
The scientific thesis: psychiatric and neurodegenerative conditions share overlapping
genetic, neural, and behavioral structure. Current categorical diagnoses impose
artificial boundaries on this continuum. A foundation model trained on a broad
aggregation of modalities can learn a continuous coordinate system in which:
1. Cross-disorder relationships are structurally encoded (not imposed).
2. Within-disorder heterogeneity (biotypes) is recoverable across modalities.
3. Individual trajectories under treatment are trackable.
Neuroverse is the map. Cytonome is the sensor that places a person on it.
``mermaid
graph TB
NV[Neuroverse Program]
NV --> SCI[Scientific Outputs]
NV --> DATA[Data & Access]
NV --> INFRA[Infrastructure]
NV --> COLLAB[Collaborators]
SCI --> FM[Foundation Model weights
open after member-inference eval]
SCI --> PUB[Publications + validation metrics]
SCI --> CODE[Training pipelines — open-source]
DATA --> BATCH1[Batch 1: Molecular
NBB · PEC · PsychAD · ROSMAP]
DATA --> BATCH2[Batch 2: Connectomics + Population
HCP · ABCD · UK Biobank · B-SNIP]
DATA --> BATCH3[Batch 3: Clinical EHR
All of Us · MVP · MGB Biobank · Mayo]
INFRA --> SAE[Cytognosis Secure Analysis Env
GCP cytognosis-phi-prod]
INFRA --> REED[Purdue REED+
HPC + Physical AI Center]
INFRA --> ERIS[McLean ERIS
postmortem molecular datasets]
COLLAB --> BRAD[Brad Ruzicka MD PhD
McLean · MGB · Harvard
Site PI — genomics]
COLLAB --> ANANTH[Ananth Grama PhD
Purdue Physical AI Center
Site PI — connectomics + compute]
``
The Neuroverse coordinate system must satisfy three independent scientific claims.
Satisfying all three is the acceptance criterion.
| Level | Claim | Key Datasets | Primary Metrics |
|---|---|---|---|
| 1 — Transdiagnostic | Recovers cross-disorder relationships from RDoC/HiTOP/PGC structure | NBB, PEC, PsychAD, ROSMAP, B-SNIP | Procrustes alignment vs HiTOP spectra; disorder dendrogram cophenetic correlation |
| 2 — Within-disorder biotypes | Recovers published biotypes across modalities (e.g., Drysdale depression, Clementz psychosis) | B-SNIP, ROSMAP, PEC, ABCD | ARI/NMI vs published biotype labels; cross-modality biotype transfer AUC |
| 3 — Treatment dynamics | Individual coordinate shifts are interpretable and track intervention response | Longitudinal ABCD, dense-sample clinical cohorts | Cohen's d pre/post; responder vs non-responder AUC; ICC for coordinate stability |
| Role | Person | Institution | Contact |
|---|---|---|---|
| Principal Investigator | Shahin Mohammadi, PhD | Cytognosis Foundation | mohammadi@cytognosis.org |
| Site PI — Genomics & Single-Cell | Brad Ruzicka, MD PhD | McLean Hospital / MGB / Harvard | via mohammadi@cytognosis.org |
| Site PI — Connectomics & Compute | Ananth Grama, PhD | Purdue University (Physical AI Center) | via mohammadi@cytognosis.org |
| Doc | Purpose |
|---|---|
| datasets-cohorts.md | Full cohort table: modalities, access routes, DUC status, data tiers |
| infrastructure.md | Secure Analysis Environment design, inter-institutional access patterns |
| action-plan.md | IRB, DUC submission sequence, onboarding flow, roadmap |
| Section | Why it's related |
|---|---|
| Data Strategy | Governance, HIPAA, DMP, DUA templates that apply to Neuroverse |
| HIPAA Status | Compliance controls for PHI handling |
| NIH GDS Requirements | DUC obligations, NIST 800-171, generative AI restrictions |
| Reproducibility Strategy | How Neuroverse runs emit FAIR RO-Crates |
| Dataset Catalog | Broader public dataset catalog (Neuroverse is a subset) |
| Milestone | Status |
|---|---|
| Scientific strategy documented | ✅ Done |
| Collaborator MOUs (Cytognosis–Purdue, Cytognosis–McLean) | ⏳ Drafted by Duane; not yet signed |
| North Star IRB Support Agreement | ✅ Executed |
| SMART IRB Joinder (Cytognosis as relying institution) | ⏳ Pending FWA issuance |
| FWA (Federal Wide Assurance) from OHRP | ⏳ Application in progress |
| Secure Analysis Environment (GCP phi-prod) | ✅ Provisioned (empty) |
| First DUC submitted (NBB) | ⏳ Pending FWA + IRB |
| First data ingested | ⏳ Pending first DUC approval |
| Foundation model training begins | ⏳ Pending sufficient multi-cohort data |